EASY
Diploma
IMPORTANT
Earn 100

"In the field of observation, chance favours the prepared mind"- Louis Pasteur. Using the discovery of penicillin as an example, discuss the influence of an open-minded attitude on our perceptions.

Important Questions on Medicinal Chemistry

EASY
Diploma
IMPORTANT
Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 1
Explain the meanings of the terms lethal dose (LD50), toxic dose (TD50) and effective dose (ED50). 
EASY
Diploma
IMPORTANT
Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 1
Hydrochloric acid is primarily responsible for the acidity of gastric juice. Calculate the concentration, in mol dm-3 and mass percentage of hydrochloric acid in the sample of gastric juice with pH 1.5 and density 1.03 kg dm-3.
EASY
Diploma
IMPORTANT
Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 2

A well-known brand of antacids contains 0.160 g of aluminium hydroxide and 0.105 g of magnesium carbonate in each tablet.

Determine which of the two components of the tablet will neutralise the most acid?

EASY
Diploma
IMPORTANT
Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 4
Two substances commonly used in antacid tablets are magnesium hydroxide and aluminium hydroxide. Suggest why compounds such as sodium hydroxide or potassium hydroxide cannot be used as antacids?
EASY
Diploma
IMPORTANT
Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 4
State the names of two functional groups that are present in zanamivir but not in oseltamivir.
EASY
Diploma
IMPORTANT
Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 7
Many technological processes of green chemistry involve the use of supercritical carbon dioxide as solvent, hydrogen peroxide as oxidant, and molecular hydrogen as reducing agent. Explain how these compounds reduce the environmental impact of the chemical industry? 
EASY
Diploma
IMPORTANT
Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 3
In theory, it would take an infinite time for all the unstable nuclei in a sample of a radionuclide to decay. However, the activity of radionuclide decreases sharply within 5-10 periods of their half-lives. Calculate the percentage of a radionuclide that will remain after 5-half-life periods.
EASY
Diploma
IMPORTANT
Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 6
Calculate how much of a 7.0 mg sample of lutetium-177 (t1/2=6.6 days) would remain after 30 days.