Aspirin and ibuprofen are painkillers. The structures of Aspirin and ibuprofen are shown in figure. State the number of peaks in the H 1 NMR spectrum of aspirin (ignore the peaks due to the hydrogen atoms on the benzene ring and the reference sample).

Aspirin and ibuprofen are painkillers. The structures of Aspirin and ibuprofen are shown in figure below: There are two peaks observed in the H 1 NMR spectrum of aspirin, one peak with respect to hydrogen atom of - OH group in - COOH functional group and the another peak with respect to hydrogen atoms of - CH 3 group (the peaks due to the hydrogen atoms on the benzene ring and the reference sample are ignored).

Aspirin and ibuprofen are painkillers. The structures of Aspirin and ibuprofen are shown in figure. State the number of peaks in the H 1 NMR spectrum of aspirin (ignore the peaks due to the hydrogen atoms on the benzene ring and the reference sample).

Aspirin and ibuprofen are painkillers. The structures of Aspirin and ibuprofen are shown in figure below: There are two peaks observed in the H 1 NMR spectrum of aspirin, one peak with respect to hydrogen atom of - OH group in - COOH functional group and the another peak with respect to hydrogen atoms of - CH 3 group (the peaks due to the hydrogen atoms on the benzene ring and the reference sample are ignored).

Describe the splitting pattern for each of the peaks in H 1 NMR spectrum of aspirin.

The structure of aspirin is shown in figure below: There are two peaks observed in the H 1 NMR spectrum of aspirin, one peak with respect to hydrogen atom of - OH group in - COOH functional group and the another peak with respect to hydrogen atoms of - CH 3 group (the peaks due to the hydrogen atoms on the benzene ring and the reference sample are ignored). There is no splitting in the peaks as there are no adjacent non-equivalent hydrogen atoms to these two groups, therefore both the peaks are singlets.

EASY

Diploma

IMPORTANT

Earn 100

Aspirin and ibuprofen are painkillers. The structures of Aspirin and ibuprofen are shown in figure.

State the number of peaks in the ${}^{1}H$ NMR spectrum of aspirin (ignore the peaks due to the hydrogen atoms on the benzene ring and the reference sample).

Important Questions on Medicinal Chemistry

MEDIUM

Diploma

IMPORTANT

Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 2

Describe the splitting pattern for each of the peaks in ${}^{1}H$ NMR spectrum of aspirin.

Question Image

EASY

Diploma

IMPORTANT

Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 2

State how the infrared spectra of aspirin and ibuprofen will differ in the region

1700 - 1750 {cm}^{- 1}

EASY

Diploma

IMPORTANT

Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 3

Pharmacological properties of drugs depend upon their polarities. The partition coefficient of a certain drug between cellular tissues and blood plasma is

125

. Calculate the concentration, in

μmol {dm}^{- 3}

, this drug in tissues if its concentration in the blood plasma is maintained at

0.60 μmol {dm}^{- 3}

by continuous injection.

EASY

Diploma

IMPORTANT

Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 4

Extraction is an important technique in medicinal chemistry. Outline how a mixture of two organic compounds with different polarities can be separated by extraction.

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Diploma

IMPORTANT

Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 4

The partition of a pharmaceutical drug (

X

) between water and an organic solvent can be represented by the equation,

X (aq) \overset{}{⇌} X (org)

. Deduce the equation for the partition coefficient of

X

EASY

Diploma

IMPORTANT

Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 4

An aqueous solution with

c (X) = 0.46 mol {dm}^{- 3}

was extracted with an equal volume of Octan-

1

-ol. After the extraction, the concentration of

X

in the aqueous phase decrease to

0.012 mol {dm}^{- 3}

. Calculate the concentration of

X

in the organic phase and the

\log P

value for this drug.

EASY

Diploma

IMPORTANT

Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 5

Anabolic steroids are used by some athletes as performance-enhancing substances. Explain how steroids and other illegal drugs can be detected in the human body chromatography and mass spectrometry?

MEDIUM

Diploma

IMPORTANT

Oxford IB Diploma Programme Chemistry Course Companion>Chapter 25 - Medicinal Chemistry>Questions>Q 6

Ethanol is sufficiently volatile to pass into the lungs from the bloodstream. The roadside breathalyzer uses potassium dichromate (

VI

), which reacts with ethanol present in the breath. Deduce the oxidation and reduction half-equations that occur in the breathalyzer.

Aspirin and ibuprofen are painkillers. The structures of Aspirin and ibuprofen are shown in figure. State the number of peaks in the H1 NMR spectrum of aspirin (ignore the peaks due to the hydrogen atoms on the benzene ring and the reference sample).

Important Questions on Medicinal Chemistry

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Aspirin and ibuprofen are painkillers. The structures of Aspirin and ibuprofen are shown in figure.

State the number of peaks in the ${}^{1}H$ NMR spectrum of aspirin (ignore the peaks due to the hydrogen atoms on the benzene ring and the reference sample).