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Earn 100

Differentiate between cofactors and prosthetic group.
Important Questions on Chemical Constituents of Living Cell
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Coenzyme or metal ion that is tightly bound to enzyme protein is called prosthetic group.
A complete catalytic active enzyme with its bound prosthetic group is called apoenzyme.
Select the correct option.

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Find out where transketolase and epimerase reactions occur among the following:
i) Fructose bisphosphate
ii) Sedoheptulose- Phosphate Xylulose Ribose Phosphate
iii) Ribose Phosphate Ribulose Phosphate
iv) Xylulose Phosphate Ribulose Phosphate
v) Fructose Phosphate XylulosePhosphate Erythrose Phosphate
The correct combination is

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Match the entries in column I and Column II. Which one of the following choices is correct?
Column I | Column II | ||
(a) | Haeme | (1) | Cofactor |
(b) | (2) | Vitamin | |
(c) | Zinc | (3) | Coenzyme |
(d) | Niacin | (4) | Prosthetic group |

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Name a cofactor of carboxypeptidase, a proteolytic enzyme.(Zinc/Aluminium).

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Element | Activator of | ||
---|---|---|---|
a. | Fe | (i) | Alcohol dehydrogenase |
b. | Mg | (ii) | Catalase |
c. | Zn | (iii) | Nitrogenase |
d. | Mo | (iv) | Rubisco |

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Prosthetic groups are__(A)__ compounds distinguished from other co-factors in being __(B)__ bound to the apo-enzyme. For example, in peroxidase and __(C)__ which catalyse the breakdown of hydrogen peroxide to water and__(D)__, __(E)__ is the prosthetic group.
Select the option that correctly fills blanks in the above paragraph.
(i) | organic | tightly | catalase | oxygen | haem |
(ii) | inorganic | loosely | catalase | hydrogen | haem |
(iii) | inorganic | tightly | isomerase | hydrogen | haem |
(iv) | organic | loosely | isomerase | oxygen | haem |

