HARD
AS and A Level
IMPORTANT
Earn 100
Gene therapy for diseases such as ADA-SCID and LCA is possible because they are caused by recessive alleles. Explain how it might be possible to treat or cure Huntington's disease which is caused by a dominant allele.
Important Questions on Genetic Technology
HARD
AS and A Level
IMPORTANT
Summarise the challenges posed by gene therapy that have had to be overcome by researchers.
MEDIUM
AS and A Level
IMPORTANT
Outline the different uses of recombinant DNA in the treatment of genetic diseases.
HARD
AS and A Level
IMPORTANT
What are the limits to gene therapy? Discuss the social and ethical issues surrounding this technology. Decide which procedures are ethical and which are not.
HARD
AS and A Level
IMPORTANT
Several crop species have been genetically modified to express poisons based on a toxic compound from the bacterium, B. thuringiensis (Bt). GM varieties of soya, oilseed rape, cotton, maize, and tobacco are all grown in countries such as the United States, China, and Brazil. Explain the advantages of growing Bt varieties of these crop plants.
HARD
AS and A Level
IMPORTANT
Several crop species have been genetically modified to express poisons based on a toxic compound from the bacterium, B. thuringiensis (Bt). GM varieties of soya, oilseed rape, cotton, maize, and tobacco are all grown in countries such as the United States, China, and Brazil. Outline how crop plants, such as those listed above, are genetically modified to improve productivity.
HARD
AS and A Level
IMPORTANT
Outline the potential risks of growing GM crop varieties and suggest steps that can be taken to minimise them.
MEDIUM
AS and A Level
IMPORTANT
The table shows enzymes that are used in gene technology. Complete the table to show the role of each enzyme.
| Enzyme | Role |
| DNA ligase | |
| DNA polymerase | |
| restriction enzyme | |
| reverse transcriptase | |
| Cas9 |
HARD
AS and A Level
IMPORTANT
Explain why it is easier to devise a gene therapy for a condition caused by a recessive allele than for one caused by a dominant allele.
