Michaelis constant $\left({\mathrm{K}}_{\mathrm{m}}\right)$ value of enzyme is substrate concentration at which velocity of reaction is

Study the following statements :
(i) The substrate binds to the active site of the enzyme.
(ii) Enzymes isolated from thermophilic organisms get denatured at $50°\mathrm{C}$.
(iii) The active site of enzyme breaks the chemical bonds of the product.
(iv) Prosthetic groups are tightly bound to the apoenzyme.

Select the option which includes all correct statements: