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The conversion of an amide to an amine with one carbon atom less by the action of alkaline hydrohalite is known as Hofmann degradation.

RCONH 2 + Br 2 + 4 KOH → RNH 2

The most important feature of the reaction is the rearrangement of N-bromamide anion to isocyanate

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Hofmann reaction is accelerated if the migrating group is more electron releasing.

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The product will be

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Important Questions on Amines

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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
The most appropriate reagent for conversion of C2H5CN into CH3CH2CH2NH2 is :
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An aromatic compound 'A' having molecular formula C7H6O2, on treating with aqueous ammonia and heating forms compound ′B′. The compound ′B′ on reaction with molecular bromine and potassium hydroxide provides compound ′C′ having molecular formula C6H7N. The structure of ′A′ is:
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
The best reagent for converting, 2-phenylpropanamide into 1- phenylethanamine is _____.
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines

Starting from propanoic acid, the following reactions were carried out 
Propanoic acid ⟶SOCl2X⟶NH3Y⟶Z2+KOH→Z

What is the compound Z?

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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
In the Hoffmann bromamide degradation reaction, the number of moles of NaOH and Br2 used per mole of amine produced are:
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
Reaction of propanamide with ethanolic sodium hydroxide and bromine will give
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
Which one of the following can be prepared by Gabriel phthalimide synthesis?
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines

Identify 'A' in the following reaction R-NO2→neutral medium Zn/NH4ClA+H2O

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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
Which of the following amines can be prepared by Gabriel phthalimide reaction?
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
Which of the following is not a correct method of the preparation of benzyl amine from cyano benzene?
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines

In the reaction, 

CH3·CH2·Cl⟶KCNA⟶LiAlH4P end product P is

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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
Which of the following statements is incorrect in case of Hofmann bromamide degradation?
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
Which one of the following compounds undergoes Hoffmann degradation reaction?
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
Which of the following compounds can be prepared in good yield by Gabriel phthalimide synthesis ?
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What are P and Q in the following reactions?

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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
What are X, Y and Z in the following reaction sequence?
 Phthalamide ⟶ Strongheating X⟶KOH/C2H5OH,Y⟶RX,Z
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
When alkyl halide is boiled with large excess of alcoholic ammonia it forms
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Ethylamine C2H5NH2 can be obtained from N-ethylphthalimide on treatment with:
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
Which of the following reaction is appropriate for converting acetamide to methanamine?
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Chemistry>Organic Chemistry>Amines>Methods of Preparation of Amines
The electrolytic reduction of nitrobenzene in strongly acidic medium produces: