EASY
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Which was the first genetic material to be discovered, whether DNA or RNA?

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Important Questions on Molecular Basis of Inheritance

EASY

Identify the labels marked A, B, C, D in a sequence in the illustrated diagram.

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MEDIUM

A bacterial strain S was heat killed. Another strain R (living) was taken and mixed with this S strain. This mixture of S+R strains were injected into mice. Which of the following are observed by Griffith?

I. The cells of S strain were dead in dead mice.

II. The bacterial cells without polysaccharide coat are transformed into virulent strain in the injected mice.

II. Griffith could not find living S strain in the body of dead mice.

IV. Griffith could find living S strain in the body of dead mice.

The correct combination is:

MEDIUM
Choose the wrong statements from the given below
A) Lederberg and Tatum found that the bacterium donates entire genetic material to recipient
B) Ehrenberg established link between bacteria and infectious diseases
C) Pasteur showed about the significant changes of nature brought by bacteria
D) Griffith discovered recipient cells of bacteria acquire previous characters
EASY
Frederick Griffith performed an experiment where mice were killed when injected with a mixture of Heat-Killed S-type Streptococcus (HKS) and Live R-type Streptococcus (LRS) but not with HKS or LRS separately. Mice were killed because
MEDIUM
Choose the incorrect statements.
(A) Transformation was not inhibited by protease and DNase.
(B) Transformation was affected by protease and DNase.
(C) Transformation was affected by RNase.
(D) Transformation was affected by DNase.
MEDIUM
A molecule that can act as a genetic material must fulfill the traits given below, except
MEDIUM
Choose the incorrect statements from the following:
A) A nitrogen base is linked to the sugar through peptide linkage to form a nucleoside.
B) A polynucleotide chain has free phosphate moiety at 5 end of sugar.
C) In RNA, nucleotide residue has an additional --OH group at 2nd the position of the ribose sugar.
D) It is observed that in DNA, the A: T ratio and C: G ratio are not constant all the time.
EASY
In an experiment, bacteria were infected with P32 labelled virus in a ratio of 5:1. The culture was rigorously shaken followed by centrifugation. Radioactivity was:
MEDIUM
Match the scientists of Column - I with their contributions in Column - II
  Column - I   Column - II
i Griffith p Lac Operon
ii Jacob and Monad q DNA is the genetic material
iii Meselson and Stahl r Transforming principle
iv Hershey and Chase s DNA replicates semi-conservatively
EASY
What was the key finding from Griffith's experiments using live and heat-killed pathogenic bacteria?
HARD
Arrange the following biological discoveries in the correct chronology from the earliest to the latest.
i. British biochemist Frederick Sanger introduces his 'plus and minus' method for DNA sequencing.
ii. American scientists Walter Gilbert and Allan Maxam introduce their method of DNA sequencing using chemical processes to terminate DNA strands.
iii. Swiss physician Friedrich Miescher discovers and isolates DNA
iv. Canadian-American researchers Oswald Avery and Colin Munro MacLeod, along with American geneticist Maclyn McCarty, working on experiments on pneumococcal bacteria, establish that DNA could transform the properties of cells.
v. American biologist James Watson and English physicist Francis Crick discover the double helix when solving the three-dimensional structure of DNA, working from crystallographic data produced by Rosalind Franklin and Maurice Wilkins.
EASY

A student grew virus in three different media containing P32, S35 and DNAase separately and allow this virus to attack to E. coli. The series of observation made by the students are as follows:

a) P32 labelled phage particles were produced in E. coli.
b) S35 containing phage particles were produced E. coli.
c) Phage particles were observed in E. coli.

d) P32 was not observed in phage particles produced by E. coli.
e) S35 was not observed in phage particles produced by E. coli.

The correct observations are

EASY
The final proof for DNA as the genetic material came from the experiments of
MEDIUM
Identify the correct order of organization of genetic material from largest to smallest :