HARD
AS and A Level
IMPORTANT
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Why are pure enantiomers rather than racemic mixtures the better option for use as pharmaceutical drugs from the point of view of a pharmaceutical company?

Important Questions on Organic Synthesis

HARD
AS and A Level
IMPORTANT
Chemistry for Cambridge International AS & A Level Coursebook with Digital Access (2 Years)>Chapter 29 - Organic Synthesis>Question>Q 1
Why are modern chiral catalyst-based processes or using enzymes for manufacturing pure enantiomers more sustainable (environmentally friendly) than traditional synthetic routes used by the pharmaceutical industry?
HARD
AS and A Level
IMPORTANT
Chemistry for Cambridge International AS & A Level Coursebook with Digital Access (2 Years)>Chapter 29 - Organic Synthesis>Question>Q 1
Find out why the drug thalidomide resulted in Iegal action against its manufacturer.
HARD
AS and A Level
IMPORTANT
Chemistry for Cambridge International AS & A Level Coursebook with Digital Access (2 Years)>Chapter 29 - Organic Synthesis>REFLECTION>Q 1
Reflect on how a molecule containing two chiral centres could have no effect on plane-polarised light.
HARD
AS and A Level
IMPORTANT
Chemistry for Cambridge International AS & A Level Coursebook with Digital Access (2 Years)>Chapter 29 - Organic Synthesis>REFLECTION>Q 2
Discuss your ideas about why the pairs of enantiomers differ in their effectiveness as drugs. Think about the role of active sites in enzymes how do they work.
MEDIUM
AS and A Level
IMPORTANT
Chemistry for Cambridge International AS & A Level Coursebook with Digital Access (2 Years)>Chapter 29 - Organic Synthesis>Question>Q 2

Show a sequence of reactions to plan how the following conversions can be made in two or three-step synthesis. Include the conditions required for the reaction. Start by drawing the structural formulae of the initial and final compounds.

  • ethene to ethyl amine
HARD
AS and A Level
IMPORTANT
Chemistry for Cambridge International AS & A Level Coursebook with Digital Access (2 Years)>Chapter 29 - Organic Synthesis>Question>Q 2

Show a sequence of reactions to plan how the following conversions can be made in two or three-step synthesis. Include the conditions required for the reaction. Start by drawing the structural formulae of the initial and final compounds.

  • benzaldehyde to ethyl benzoate
HARD
AS and A Level
IMPORTANT
Chemistry for Cambridge International AS & A Level Coursebook with Digital Access (2 Years)>Chapter 29 - Organic Synthesis>Question>Q 2

Show a sequence of reactions to plan how the following conversions can be made in two or three-step synthesis. Include the conditions required for the reaction. Start by drawing the structural formulae of the initial and final compounds.

  • 1-bromo butane to butanoic acid
HARD
AS and A Level
IMPORTANT
Chemistry for Cambridge International AS & A Level Coursebook with Digital Access (2 Years)>Chapter 29 - Organic Synthesis>Question>Q 2

Show a sequence of reactions to plan how the following conversions can be made in two or three-step synthesis. Include the conditions required for the reaction. Start by drawing the structural formulae of the initial and final compounds.

  • Butane-2-one to 2-aminobutane