Drug-Target Interaction
Drug-Target Interaction: Overview
This topic covers concepts such as Drug-Target Interaction, Enzymes, Receptors, Enzymes as Drug Targets, Catalytic Action of Enzymes, Drug-Enzyme Interaction : Enzyme Inhibition, Receptor as Drug Targets, Enzyme Inhibitors, etc.
Important Questions on Drug-Target Interaction
Which of the following is not related to drug-enzyme interaction?
The chemicals which carry different messages in the body between neurons and muscles are called ______.
Which of the following is INCORRECT?
The substrate molecules are held by enzymes with ______.
The enzymes which are cruical to communication system are called ______.
The drugs which bind the receptors and disturb their functions are called _____.
Which among the following can serve as target molecule for drug interaction?
The drugs which interact with target biomolecules are called _____.
Arrange the sequences in enzyme action
(A) Product releases and free enzyme again binds to another substrate molecule
(B) Enzyme to alter its shape
(C) Substrate binds to active site of the enzyme
(D) Fits in to the active site
(E) Formation of enzyme product complex
The correct answer is
Assertion:- Non compelitive inhibitors alters the active site of enzymes.
Reason:- Non competitive inhibitors always bind with active site.
Assertion:- Antihistamine does not effect acid secretion of stomach.
Reason:- Antacid and antihistamine acts on different receptors.
Which of the following statement is incorrect?
Among the following which drugs mimic natural messengers ?
Which enzyme hydrolyses triglycerides to fatty acids and glycerol
Which of the following enzymes don't have heme as a prosthetic group?
The enzyme which converts maltose to glucose is
The correct match between Item I and Item II is:
| Item-I | Item-II | ||
| (A) | Allosteric effect | (P) | Molecule binding to the active site of enzyme |
| (B) | Competitive inhibitor | (Q) | Molecule crucial for communication in the body |
| (C) | Receptor | (R) | Molecule binding to a site other than the active site of enzyme |
| (D) | Poison | (S) | Molecule binding to the enzyme covalently |
Correct matching is
| Column-I | Column-II | ||
| Allosteric site | These bind to a different site of enzyme | ||
| Poison | It binds to the active site | ||
| Receptor | It binds at active site by covalent bond | ||
| Competitive inhibitor | Important for communication | ||
Jacob and Monod named some enzymes as allosteric whose activity is regulated by
The site of action of insulin is
