Chromosomal Disorder in Humans

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Chromosomal Disorder in Humans: Overview

This Topic covers sub-topics such as Turner’s Syndrome, Klinefelter’s Syndrome, Down’s Syndrome, Patau Syndrome, Chromosomal Disorders and, Chromosomal Aberrations in Human

Important Questions on Chromosomal Disorder in Humans

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XO chromosomal abnormality in humans causes _____.

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Identify the incorrect statement about pedigree analysis.

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In which of the following genetic conditions, each nucleated somatic cells in the affected person have three copies of chromosome 21?

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Due to non-disjunction of chromosomes during spermatogenesis, sperms carry both sex chromosomes (22A + XY) and some sperms do not carry any sex chromosome (22A + O). If these sperms fertilize normal eggs (22A + X), what types of genetic disorders appear among the offsprings?

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Which of the following statement is/are correct for Turner’s syndrome ?

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Due to non-disjunction of chromosomes during spermatogenesis, sperms carry both sex chromo-somes (22 A + XY) and some sperms do not carry any sex chromosome (22 A + O). If these sperms fertilise normal eggs (22 A + X), what type of genetic disorders appear among the offspring ?

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How many chromosomes may be present in Klinefelter syndrome?

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Name the chromosomal disorder which is caused by the presence of an additional copy of the chromosome number 21.

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Which chromosomal disorder is caused by non-disjunction and denoted as 44+XXY?

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Select the correct option which is an example of sex chromosome abnormality.

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Study the following statements
I) Karyotype of Klinefelter's syndrome is AA + XO
II) Turner's syndrome is an example for trisomy
III)   AA+XX+21st  chromosome is the karyotype of Down's syndrome
IV) Individual with Klinefelter's syndrome is Barr body positive

Among the above, correct statements are

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Down's syndrome is a genetic condition that causes delays in physical and intellectual development. The cause of this genetic disorder is.

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Match the following

  List - I   List - II
a Down syndrome i Trisomy of 13th chromosome
b Edwards syndrome ii Partial delection of short arm of chromosome 5
c Patau syndrome iii Trisomy of chromosome 21
d Cri-du-chat syndrome iv Trisomy of 18th chromosome
The correct answer is

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Philadelphia chromosome is associated with following disease

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How many Barr bodies are present in the cells of Klinfelter Male KM, Normal Male M and Normal Female F in humans

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Study the following statements.
I. Aneuploidy is a chromosomal aberration where there is a gain or loss of one or more chromosomes in a set.
II. Karyotype of Klinefelter syndrome is 47, XXY.
III. Turner syndrome females have a Barr body in their somatic cells.
IV. Down syndrome is a genetic disorder due to the presence of an additional copy of the X chromosome to the normal number of chromosomes.

Among the above, the incorrect statements are

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Study the following statements

(I) Karyotype of Klinefelter's syndrome is AA + XO

(II) Turner's syndrome is an example for trisomy

(III) AA+XX+21st chromosome is the karyotype of Down's syndrome

(IV) Individual with Klinefelter's syndrome is Barr body positive Among the above, correct statements are

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Conditions of a karyotype 2n±1 and 2n±2 are called

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Which one of the following is sex chromosomal disorder?

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XXY chromosome complement is found in